begin with the brief introduction of ALS and ice bucket challenge.(to attract interests）
explain:Why there are no cure for rare disease? Because it costs a lot but not that common used and because of only few people need,it not profitable...so,no company is willing to invest this ...
So, are their life not worth to be saved? Of cause not ! they deserve to have normal life.
finally, introduce some scientice way and what could do to improve it.